Showing posts with label Genetics. Show all posts
Showing posts with label Genetics. Show all posts

Genetics: A Conceptual Approach


Genetics: A Conceptual Approach
By Benjamin Pierce




  • Publisher: W. H. Freeman
    Number Of Pages: 736
    Publication Date: 2002-12-20
    ISBN-10 / ASIN: 1572591609
    ISBN-13 / EAN: 9781572591608

  • Binding: Paperback




Principles of Genetics w/Genetics: From Genes to Genomes









Principles of Genetics w/Genetics: From Genes to Genomes CD-ROM and Website Password Card
By Robert H Tamarin




  • Publisher: McGraw-Hill Science/Engineering/Math

  • Number Of Pages:

  • Publication Date: 2001-08-04

  • ISBN-10 / ASIN: 007248523X

  • ISBN-13 / EAN: 9780072485233

  • Binding: Paperback





Book Description:

Principles of Genetics, 7/e offers an up-to-date, balanced treatment of the major areas of genetics (classical, molecular, and population genetics) in a friendly writing style with excellent learning aids, making it easier for students to learn and succeed.


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Principles of Developmental Genetics





Principles of Developmental Genetics
By Sally A. Moody




  • Publisher: Academic Press

  • Number Of Pages: 1104

  • Publication Date: 2007-06-29

  • ISBN-10 / ASIN: 0123695481

  • ISBN-13 / EAN: 9780123695482

  • Binding: Hardcover




Book Description:

Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.

Includes new research not previously published in any other book on the molecular genetic
processes that regulates development
Chapters present a broad understanding on the application of animal model systems, allowing
researchers to better treat clinical disorders and comprehend human development
Relates the application of new technologies to the manipulation of stem cells, causes of
human birth defects, and several human disease conditions
Each chapter includes a bulleted summary highlighting clinical aspects of animal models

Principles of Genetics 7th Edition

Principles of Genetics 7th Edition



ISBN: 0072334193 | The McGraw Hill | PDF | 69 MB | 685 pages | 2001

The twentieth century began with the rediscovery of Mendel’s rules of inheritance and ended with the complete sequence of the human genome, one of the most monumental scientific accomplishments of all time. What lies in the future? What will the twenty-first century, the century of genomics, bring? Will geneticists a hundred years from now speak of a complete cure for cancer, heart disease, and mental illness? Will we have a cure for autoimmune diseases such as diabetes and arthritis? Will aging be slowed or even prevented? Will we have a complete understanding of the process of development and a concurrent elimination of birth defects and developmental problems? Will genetics put an end to world hunger? How will we live, and what will be the quality of our lives? The students who now are taking genetics will learn the answers to these questions as time progresses. Some students will contribute to the answers.


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RNA Interference Technology: From Basic Science to Drug Development


RNA Interference Technology: From Basic Science to Drug Development
By Andrew Fire, Marshall Nirenberg, Krishnarao Appasani

Publisher: Cambridge University Press
Number Of Pages: 544
Publication Date: 2005-01-17
ISBN-10 / ASIN: 0521836778
ISBN-13 / EAN: 9780521836777
Binding: Hardcover

RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this cutting-edge overview, the basic concepts of RNAi biology are discussed, as well as the current and potential applications. Leading experts from both academia and industry have contributed to this invaluable reference for graduate students, post-docs and researchers from academia wanting to initiate RNAi research in their own labs, as well as for those working in research and development in biotech and pharmaceutical companies who need to understand this emerging technology. Forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.

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Methods in Mind (









Methods in Mind (Cognitive Neuroscience)
By Carl Senior, Tamara Russell, Michael S. Gazzaniga




  • Publisher: The MIT Press

  • Number Of Pages: 394

  • Publication Date: 2006-07-03

  • ISBN-10 / ASIN: 0262195410

  • ISBN-13 / EAN: 9780262195416

  • Binding: Hardcover





Book Description:

The evolution of cognitive neuroscience has been spurred by the development of increasingly sophisticated investigative techniques to study human cognition. In Methods in Mind, experts examine the wide variety of tools available to cognitive neuroscientists, paying particular attention to the ways in which different methods can be integrated to strengthen empirical findings and how innovative uses for established techniques can be developed. The book will be a uniquely valuable resource for the researcher seeking to expand his or her repertoire of investigative techniques.

Each chapter explores a different approach. These include transcranial magnetic stimulation, cognitive neuropsychiatry, lesion studies in nonhuman primates, computational modeling, psychophysiology, single neurons and primate behavior, grid computing, eye movements, fMRI, electroencephalography, imaging genetics, magnetoencephalography, neuropharmacology, and neuroendocrinology. As mandated, authors focus on convergence and innovation in their fields; chapters highlight such cross-method innovations as the use of the fMRI signal to constrain magnetoencephalography, the use of electroencephalography (EEG) to guide rapid transcranial magnetic stimulation at a specific frequency, and the successful integration of neuroimaging and genetic analysis. Computational approaches depend on increased computing power, and one chapter describes the use of distributed or grid computing to analyze massive datasets in cyberspace. Each chapter author is a leading authority in the technique discussed.

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Neuropsychiatry and Behavioral Neuroscience






Neuropsychiatry and Behavioral Neuroscience
By Jeffrey L. Cummings, Michael S. Mega




  • Publisher: Oxford University Press, USA

  • Number Of Pages: 432

  • Publication Date: 2003-01-21

  • ISBN-10 / ASIN: 0195138589

  • ISBN-13 / EAN: 9780195138580

  • Binding: Hardcover





Book Description:

This is the long-awaited successor to Jeffrey Cummings' classic work, Clinical Neuropsychiatry, published in 1985. That book represented an integration of behavioral neurology and biological psychiatry into a single volume devoted to explicating brain-behavior relationships. It was clinically oriented and intended for practitioners caring for patients with neuropsychiatric disorders. The new title reflects the authors' effort to link the recent explosion of new information from neurochemistry, neuroanatomy, genetics, neuropharmacology, neuropathology, and neuroimaging to the clinical descriptions. Yet the clinical emphasis of its predecessor has been maintained. Each chapter has a consistent approach and the book as whole provides a practical, easy-to-use synthesis of clinical advice and basic science. The volume is enhanced by 4-color images throughout. It is intended for students, residents, fellows, and practitioners of neurology, psychiatry, neuropsychology, and cognitive neuroscience. It will also be of interest to individuals in neuroimaging.


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A Dictionary of Genetics






A Dictionary of Genetics
By Robert C. King, William D. Stansfield, Pamela K. Mulligan




  • Publisher: Oxford University Press, USA
    Number Of Pages: 608
    Publication Date: 2006-07-13
    SBN-10 / ASIN: 0195307623
    ISBN-13 / EAN: 9780195307627

  • Binding: Hardcover




Book Description:

The publication of this fully updated edition of A Dictionary of Genetics coincides with the hundredth anniversary of the introduction of the term genetics by William Bateson in 1906 at the Third International Conference on Genetics. Since then genetics has made tremendous advances in knowledge and technique and now occupies a pivotal position in the life sciences as the most powerful means for probing fundamental questions in cell biology, development, and evolution. The determination of sequences of complete genomes, the study of gene expression and genetic variation on a global scale, and the ability to rapidly amplify gene sequences and to achieve targeted gene disruptions are just some examples of major achievements in this field. Proliferation of new terms inevitably accompanies such remarkable progress. This new edition of the Dictionary addresses the needs of students, educators, and clinical geneticists for an authoritative and up-to-date reference work that not only defines the latest terms, but in most cases, also presents important ancillary encyclopedic information. A Dictionary of Genetics is unique in that it includes terms from a wide range of disciplines which now intertwine with genetics, including molecular biology, cell biology, medicine, botany, and evolutionary studies. Its 7,000 cross-referenced definitions are supported by an excellent collection of line drawings, tables, and chemical formulae. One-fifth of the Dictionary is devoted to six appendices to which the definitions are cross-referenced and which contain an extraordinary trove of supplementary information. This includes a chronology of important advances spanning the years 1590 to 2005, lists of useful internet sites and periodicals, a classification of living organisms into an evolutionary hierarchy, and a sample table of genome sizes and gene numbers. These features make A Dictionary of Genetics a lexicon unparalleled in the field. For the first time, the Dictionary is available on Oxford Reference Online (ORO): Premium Collection.


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Population Genetics: A Concise Guide






Population Genetics: A Concise Guide
By John H. Gillespie




  • Publisher: The Johns Hopkins University Press
  • Number Of Pages: 192
  • Publication Date: 1997-09-05
  • ISBN-10 / ASIN: 0801857554
  • ISBN-13 / EAN: 9780801857553

  • Binding: Paperback





Book Description:


"In a species with a million individuals," writes John H. Gillespie, "it takes roughly a million generations for genetic drift to change allele frequencies appreciably. There is no conceivable way of verifying that genetic drift changes allele frequencies in most natural populations. Our understanding that it does is entirely theoretical. Most population geneticists are not only comfortable with this state of affairs, but revel in the fact that they can demonstrate on the back of an envelope, rather than in the laboratory, how an important evolutionary force operates."
Longer than the back of an envelope but more concise than many books on the subject, this brief introduction to the field of population genetics offers students and researchers an overview of a discipline that is of growing importance. Chapter topics include genetic drift; natural selection; non-random mating, quantitative genetics; and the evolutionary advantage of . While each chapter treats a specific topic or problem in genetics, the common thread throughout the book is what Gillespie calls "the main obsession of our field," the recurring question, "Why is there so much genetic variation in natural populations?"
"Population genetics remains the central intellectual connection between genetics and evolution. As genetics becomes integral to all aspects of biology, the unifying nature of evolutionary studies rests more and more on population genetics. This book lays out much of the foundation of population genetics augmented with interesting particulars and conceptual insight. Population genetics involves ideas that are quantitative and often difficult for biology undergraduates, but Professor Gillespie offers his characteristically clear thinking and articulate explanations." -- Charles Langley, University of California-Davis


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Genetics of Sexual Differentiation and Sexually Dimorphic Behaviors

Genetics of ual Differentiation and ually Dimorphic Behaviors


Product Details
Book Publisher: Academic Press (08 August, 2007)
ISBN: 0120176602
Book author: Daisuke Yamamoto
Amazon Rating:

Book Description:
Volume 59 in the Advances in Genetics serial provides nine chapters on the most advanced research on the differentiating behaviors among es. With more than 300 pages of articles from leading international scientists, this volume offers genetic behaviorial information related to drosophila, mice, birds, voles, and mammals. Hot topics include differences in brain and behavior; genomic imprinting and the evolution of differences; gene regulation; peptide pheromone production and reception, and more.

* Nine chapters on the most advanced research on the differentiating behaviors among es
* More than 300 pages of articles from leading international scientists, this volume offers genetic behaviorial information related to drosophila, mice, birds, voles, and mammals
* Hot topics include differences in brain and behavior; genomic imprinting and the evolution of differences; gene regulation; peptide pheromone production and reception, and more


Gene Biotechnology Second edition

Gene Biotechnology Second edition



Product Details
Book Publisher: CRC (2004)
ISBN: 0849312884
Book author: William Wu
Amazon Rating:

Book Description:

Many scientists find themselves working in the laboratory without sufficient background in current biotechnology methods. Others want to keep up with the revolution in biotechnology and the flood of new methodologies. This book provides a solution for both: a multidisciplinary approach to the methods essential to biotechnical development. Covering state-of-the-art technologies and a broad range of practical applications, the Second Edition of Gene Biotechnology presents information that researchers and students need to understand and apply todays biotechnology techniques. It discusses a wide variety of approaches, from very basic methods to the latest, most sophisticated technologies, including gene manipulation methods. The book contains clearly detailed, step-by-step protocols with helpful troubleshooting tips. It addresses the needs of researchers in academic and commercial environments, and serves as a guide for graduate students designing, implementing, and evaluating experimental projects. Written by a team of internationally recognized scientists, this edition offers several notable features typically lacking in other works on the subject. The book presents protocols, as well as clear and simple explanations of the key principles and concepts behind the methods. It includes useful troubleshooting guides to help solve experimental problems, presenting a single, logically organized source for all the most important new methodologies. This unique resource provides the tools for success in molecular and cellular biology research today.


Translational Control of Gene Expression

Translational Control of Gene Expression



Product Details
Book Publisher: COLD SPRING HARBOR LABORATORY PRESS (15 October, 2000)
ISBN: 0879695684
Book author: Nahum, Ed. Sonenberg
Amazon Rating:

Book Description:
Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translational control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.


Genetic Programming Theory and Practice IV

Genetic Programming Theory and Practice IV



Product Details
Book Publisher: Springer (March, 2007)
ISBN: 0387333754
Book author: Rick Riolo, Terence Soule, Bill Worzel
Amazon Rating:

Book Description:

Genetic Programming Theory and Practice IV was developed from the fourth workshop at the University of Michigans Center for the Study of Complex Systems to facilitate the exchange of ideas and information related to the rapidly advancing field of Genetic Programming (GP). Contributions from the foremost international researchers and practitioners in the GP arena examine the similarities and differences between theoretical and empirical results on real-world problems. The text explores the synergy between theory and practice, producing a comprehensive view of the state of the art in GP application.

This volume represents a watershed moment in the GP field in that GP has begun to move from hand-crafted software used primarily in academic research, to an engineering methodology applied to commercial applications. It is a unique and indispensable tool for academics, researchers and industry professionals


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Genetic Privacy: A Challenge to Medico-Legal Norms

Genetic Privacy: A Challenge to Medico-Legal Norms



Product Details
Book Publisher: Cambridge University Press (15 June, 2002)
ISBN: 0521660270
Book author: Graeme Laurie
Amazon Rating:

Book Description:
The issue of rights to genetic information is considered in this study from the standpoint of individuals, their relatives, employers, insurers and the state. Graeme Laurie provides a concept of privacy and property rights for the person, and argues for stronger legal protection following new developments in genetics. This book will interest lawyers, philosophers and doctors concerned with genetic information and issues of privacy, as well as genetic counselors, researchers and policy makers worldwide for its practical position on dilemmas in modern genetic medicine.


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Genetics and Genomics of Neurobehavioral Disorders

Genetics and Genomics of Neurobehavioral Disorders



Product Details
Book Publisher: Humana Press (07 January, 2003)
ISBN: 158829045X
Book author: Gene S. Fisch
Amazon Rating:

Book Description:
A clear and comprehensive account of how genetic abnormalities, neurobiology, and neuropsychology work together to manifest cognitive-behavioral dysfunction. The authors review the current status of research in autosomal disorders that produce cognitive-behavioral dysfunction and syndromal and nonsyndromal disorders that produce mental retardation. Comprehensive and up-to-date, Genetics and Genomics of Neurobehavioral Disorders integrates the molecular, genomic, neuropsychological, and neurobehavioral factors that produce learning disabilities and mental retardation into a coherent framework for the understanding and assessment of neurobehavioral disorders.


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Genomic Disorders: The Genomic Basis of Disease

Genomic Disorders: The Genomic Basis of Disease



Product Details
Book Publisher: Humana Press (15 April, 2006)
ISBN: 1588295591
Book author: James R. Lupski, Pawel T. Stankiewicz
Amazon Rating:

Book Description:
A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.


Molecular Biology: Understanding the Genetic Revolution

Molecular Biology: Understanding the Genetic Revolution


By David P. Clark
Publisher: Academic Press
Number Of Pages: 816
Publication Date: 2005-06-09
ISBN-10 / ASIN: 0121755517
ISBN-13 / EAN: 9780121755515
Binding: Hardcover
Book Description:

Molecular biology is a fast-paced field that constantly provides new insights into the living world and the role of humans within it. Students and professionals need a clear understanding of new discoveries and applications, as well as a firm grasp of the fundmental concepts. Clark's Molecular Biology: Understanding the Genetic Revolution gives readers what they need in both regards.

Clark effectively introduces basic concepts followed by more specific applications as the text evolves. He has included research results as current as late 2004 when the gene count for humans was officially changed, and takes a thorough look at the medical, agricultural, and social aspects that shape modern-day molecular biology. This text is written in a straightforward manner and beautifully illustrated in full color.

Molecular Biology covers a deliberately broad range of topics to show that molecular biology is not applicable merely to human medicine and health, but also applies to veterinary medicine, evolution, agriculture, and other areas.

* Up to date description of genetic engineering, genomics, and related areas
* Basic concepts followed by more detailed, specific applications
* Hundreds of color illustrations enhance key topics and concepts
* Covers medical, agricultural, and social aspects of molecular biology
* Organized pedagogy includes running glossaries and keynotes (mini-summaries) to hasten comprehension


Genetics: From Genes to Genomes

Genetics: From Genes to Genomes with PowerWeb



Product Details
Book Publisher: McGraw-Hill Science/Engineering/Math (04 March, 2003)
ISBN: 0072462485
Book author: Leland Hartwell, Leroy Hood, Michael L. Goldberg, Lee M. Silver, Ruth C. Veres, Ann Reynolds
Amazon Rating: 3.5

Book Description:
Genetics: From Genes to Genomes is a cutting-edge, introductory genetics text authored by an unparalleled author team, including Nobel Prize winner, Leland Hartwell. The Second Edition continues to build upon the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the new molecular discoveries that have changed the way the field of genetics is viewed.


Target Discovery and Validation Reviews and Protocols, Vol 2: Emerging Molecular Tar

Target Discovery and Validation Reviews and Protocols, Vol 2: Emerging Molecular Targets and Treatment Options



By

Publisher: Humana Press
Number Of Pages: 345
Publication Date: 2007
Sales Rank: 4051980
ISBN / ASIN: 1588298906
EAN: 9781588298904
Binding: Hardcover
Book Description:

Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders.

Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products.

Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic.

Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.



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Target Discovery and Validation Reviews and Protocols, Vol 1: Emerging Strategies fo

Target Discovery and Validation Reviews and Protocols, Vol 1: Emerging Strategies for Targets and Biomarker Discovery



By Mouldy Sioud
Publisher: Humana Press
Number Of Pages: 376
Publication Date: 2006-10-15
ISBN-10 / ASIN: 1588296563
ISBN-13 / EAN: 9781588296566
Binding: Hardcover
Book Description:

Target Discovery and Validation: Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders.

Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products.

Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNA's, antisense oligonucleotides and RNA aptimers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic.

Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.