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http://www.amazon.com/Dendrimers-Med...762686&sr=11-1Dendrimers in Medicine and Biotechnology: New Molecular Tools (Hardcover)
by U. Boas (Author), J.B. Christensen (Author), P.M.H. Heegaard (Author)
Review
From the reviews ...
Dendrimers are essentially molecules that grow like trees, by branching out again and again. Ideally, chemists want to control the growth of these structures (eg by adding the branching units in a stepwise, layer-by-layer fashion) so that the resulting molecular tree is a well-defined, monodisperse molecular entity, more akin to a natural protein than to an industrial polymer.
As dendrimers have been around for over 20 years, there is a growing expectation for them to grow up and do something useful. They have shown particular promise in various parts of the transport business, including the transfer of DNA or certain drugs into the cell. Moreover, dendrimers could act as drugs themselves, if parts of their structures included suitably reactive groups. However, before one can consider throwing a new kind of molecular compound at patients, there is a lot of small print to sort out, such as toxicity, biodegradability, survival time in the organism, and transport efficiency.
Boas et al have compiled the current knowledge of what one can and cannot do with dendrimers in a biological context (ie medical or biotech applications) into a handy tome of under 200 pages. There isnt any complicated chemistry in it, so people coming from the application side should find it useful and accessible. Conversely, there is some medical terminology that comes without explanation, such that chemists may find it a little bit harder to understand.
All in all, the book should provide valuable insights for anybody interested in the chemistrybiology interface[.]
Michael Gross, CHEMISTRY WORLD, September 2006
Book Description
Dendrimers are a new class of macromolecule increasingly used in the fields of synthetic organic chemistry, biology, medicine and biotechnology. Dendrimers in Medicine and Biotechnology: New Molecular Tools looks at this exciting and rapidly growing area of science. Using an interdisciplinary approach with particular emphasis on biological applications, the book discusses the relationship between the dendrimer molecular motif and its biological properties.
A general introduction to the subject of dendrimers, including definitions of terms and symbols, is provided. Subsequent sections discuss topics including dendrimers in biological systems, dendrimers as drug delivery devices, dendrimers in diagnostics and dendrimer drugs. Throughout the book, examples from current research are also provided.
This book will appeal to a wide range of scientists, including non-specialists who require an introduction to dendrimers, as well as those wishing to know more about the applications of dendrimers in the fields of biology and medicine.
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Product Details
* Hardcover: 182 pages
* Publisher: Royal Society of Chemistry; 1 edition (June 9, 2006)
* Language: English
* ISBN-10: 0854048529
* ISBN-13: 978-0854048526
* Product Dimensions: 9.3 x 6.1 x 0.7 inches
* Shipping Weight: 15.2 ounces
List Price: $129.00
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